Higher-order thiol cell system like metallothioneins, thioredoxins, and other redox regulator proteins are ultimately regulated by reduced form of Glutathione (GSH) levels and the ratio of GSH / GSSG (oxidized GSH)
doi:10.1080/13697137.2019.1682542
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More recently, mGPDHs protective function was validated in vivo: in a mouse model of sepsis-induced acute lung injury, mGPDH knockdown exacerbated lung injury, vascular leakage, inflammation and oxidative damage, accompanied by elevated ferroptotic markers 100
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