will medicare pay for semaglutide for weight loss the first time, cover GLP-1s obesity-related loss, without any other medical conditions. Starting Wednesday, eligible Medicare beneficiaries can receive GLP-1s for obesity for $50 per month by Medicare, Medicaid to experiment with

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For diabetes patients, A1c reductions of approximately 1.0-1.5 percentage points are common with GLP-1 receptor agonists, while tirzepatide has shown reductions of up to 2.0-2.3 percentage points in clinical trials

Back Sheridan, C (14 April 2025) 'Not just obesity: GLP-1 receptor agonists advance on addiction', Nature Biotechnology , 43, 455-47.Back Sims, EK, Carr, ALJ, Oram, RA, et al (15 July 2022) '100 years of insulin: celebrating the past, present and future of diabetes therapy', Nature Medicine , 27/7, 1154-64

Major metabolites identified are trimethylamine oxide in urine and gamma-butyrobetaine in feces

For readers who want a closer look, our tirzepatide guide explains how it works in a weight loss program