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For example, investigators found that orexigenic effects of systemically administered ghrelin (also known as the hunger hormone) were abolished in CB 1 receptor knockout mice 40 , and pharmacological blockade of the CB 1 receptor, via rimonabant administration, attenuated ghrelin-induced activation of the mesolimbic dopamine system a key pathway involved in reward processing 41

October 2015

Available evidence suggests that discontinuing GLP-1 agonists leads to return of cravings, similar to how weight tends to regain after stopping treatment