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In some embodiments, the antioxidant or anti-apoptotic agent protects hair cells from chemotherapy-induced damage

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5-HTP is converted into serotonin by the enzyme hydroxytryptophan decarboxylase and with the help of vitamin B6

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Additionally, Plasmodium -derived hemozoin that accumulated in tumor-associated macrophages inhibited IGF-1 signaling through the PI3-K and MAPK signaling pathways and thereby decreased the expression of MMP-9 in tumor-associated macrophages [130]