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Riede, J.P

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Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species

A 2022 systematic review and meta-analysis of 18 randomized trials including 883 hypothyroid patients and evaluating outcomes like depression, fatigue, pain, anxiety, and anger, found no statistically significant advantage of combined LT4+LT3 therapy over LT4 monotherapy on any of these psychological endpoints (42)

This hormone is believed to be transmitted by sensory neuron cells in the gut and is rapidly metabolized there by an enzyme called dipeptidyl peptidase