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form of vitamin E not mentioned in the publication) for over two years significantly delayed functional decline determined by the (in)ability to perform basic activities of daily living and reduced the annual mortality rate in mild and moderate AD patients (111)

Furthermore, unpublished studies often lacked sufficient methodological detail for quality appraisal, outcome data, and long-term follow-up, and the absence of peer review made it difficult to appraise internal validity in a standardised way

This procedure does not affect blood flow to the legs, as the deeper veins maintain normal circulation

Phase 2 NEJM 2023: 24.2% at 48 weeks