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GLP-1 drugs also reduce levels of the hormone glucagon, which can raise blood sugar

Widely used for type 2 diabetes mellitus and obesity, glucagon-like peptide-1 receptor agonists (GLP-1RAs) may increase risk for injection-site reactions, especially exenatide and dulaglutide (Trulicity, Eli Lilly)

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Researchers specifically investigating MC4R-mediated biology often use MT-2 as the non-selective melanocortin agonist probe, with multi-receptor activity accounted for in the experimental design