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[14] If bilateral fine crackles are present throughout the inspiratory time and are persisting after several deep breaths, and if remaining present on several occasions several weeks apart in a subject aged 60 years, this should raise the suspicion of IPF and lead to consideration of an HRCT scan of the chest which is more sensitive than a chest X-ray

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The expression level of these protein was up-regulated by ASK1 signalling activation and down-regulated by ASK1 signalling suppression (Fig