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In addition, these metabolic effects do not appear to be related to their diuretic action or intended pharmacological targets, raising concerns about the long-term metabolic impact of specific diuretics, particularly in vulnerable populations, including those with metabolic syndrome

Patients with a personal or family history of medullary thyroid cancer or MEN 2 should not take either medication

High-dose niacin therapy is normally contraindicated in individuals with active peptic ulcer disease or active liver disease

Learn how to begin safely, navigate side effects, and pair your medication with simple strategies for sustainable weight loss and overall wellness

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