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It also enhances insulin sensitivity, reduces inflammation, and improves blood pressure, physical strength, exercise capacity, and key markers of aging

Our skin is exposed to sun, dust and pollution on a daily basis, which leads to overproduction of melanin and oxidative stress

By reducing cytokine release and macrophage infiltration, GLP-1-RAs inhibit chronic inflammatory processes implicated in insulin resistance and cancer development

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Apoptosis assay Cells were collected from 24-well plates, spun down and incubated in darkness at 4 C with 0.5% annexin-V-APC antibody (BD Pharmigen) and 100 g ml 1 propidium iodide dissolved in annexin-V binding buffer (1 M CaCl, 5 M NaCl, 1 M HEPES)