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Symptoms may include upper abdominal pain, fever, or yellowing of the skin or eyes (jaundice)

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Receptors on sensory afferent fibers of the nodose ganglion may also be activated, relaying impulses to central regions important in energy homeostasis, such as the NTS and the hypothalamus (93)

Bottom line: Side effects are a common part of the metabolic adjustment period, but they are generally manageable with hydration, dietary changes, and professional clinical guidance