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This observation suggests that DET1 interacts with both COP1 and Ube2e proteins, facilitating the presentation of Ube2e proteins by DET1 claw to the COP1 RING dimer

[45]Daud MK, Mei L, et al

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These researchers found that the combination of markers SOX + AKR1B10 + CD34 yielded promising sensitivity (93.8%) and specificity (95.2%) in the differentiation of WD-sHCC from HGDNs [65]