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Model: 1-compartment, first-order SC absorption

Clinical trials show that fatigue appears most often in the first 24 weeks of treatment, as your metabolism adjusts to lower food intake and weight loss begins

Some people who begin using semaglutide injections report headaches, but interestingly, one trial reported headaches in 14% of the semaglutide users and 10% in the group using the placebo, and another large clinical trial showed that the rate of individuals who reported headaches was also very close to those reported by the placebo group, so it is hard to know if the semaglutide is directly related to the headaches

While Tirzepatide injections are generally safe when administered correctly, certain symptoms or complications warrant prompt medical attention

Eur Heart J 41(2):255323