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Costunolide, a sesquiterpene lactone, demonstrated gut-brain regulatory effects in a chronic stress-induced IBS model by increasing levels of serotonin (5-HT), brain-derived neurotrophic factor, GluN2A, p-ERK1/2, and p-CREB in the hippocampus

CB-27 dilutions were prepared in DMSO (0.5% final concentration)

Los Angeles: Western Psychological Services (2003)

The detailed composition of these diets appears in a recent publication 46

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