Serious hypersensitivity reactions, including anaphylaxis and angioedema have been reported with Wegovy Warnings and Precautions Risk of Thyroid C-Cell Tumors: Patients should be further evaluated if serum calcitonin is measured and found to be elevated or thyroid nodules are noted on physical examination or neck imaging Acute Pancreatitis: Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including semaglutide
Conclusion Despite an excellent design and a pristine execution, EVOKE and EVOKE+ offer a clear, albeit sobering, lesson: promising real-world correlations and mechanistic rationale do not automatically translate into disease-modifying effects in symptomatic Alzheimers disease
When in doubt, slow down, read the fine print twice, and prioritize platforms that communicate clearly
Its important to discuss potential side effects and any pre-existing conditions with your healthcare provider before starting Wegovy
Only 0.2% of all patients (n=7,660) developed NAION