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The Steno-2 study, a long-term prospective trial with a mean follow-up of 21 years, demonstrated that early intensive multifactorial therapy, including lifestyle interventions and simultaneous pharmacological management of hyperglycemia, dyslipidemia, hypertension, and microalbuminuria, resulted in a 70% reduction in the risk of hospitalization for HF

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While nausea typically peaks during weeks 6-8 and then improves substantially, constipation can appear at any point and may persist throughout treatment