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The activation GLP-1R by GLP-1RA can restrain the activation of NF-B, thereby facilitating the apoptosis of breast cancer cells and inhibiting their proliferation

These effects are partly mediated by the melatonin receptors MT1 and MT2, which can trigger various downstream signaling pathways

Additional tests like blood tests and biopsies may be needed

For bulk RNA-seq data, we used the ssGSEA algorithm (the gsva function from the GSVA package v1.44.2) to integrate gene signatures and calculate the signature score for each sample

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