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For example, both mutations (Nashabat et al., As has been summarized previously, early studies in ASD demonstrated central deficiencies in BH4 and both controlled and open-label trials demonstrate a therapeutic effect of sapropterin in children with ASD (Frye et al., Some of the first cases of cerebral folate deficiency (CFD) were identified to have features of ASD (Ramaekers et al., 1B demonstrates the target of HDFA in the context of CFD

however, the national average has held steady at around 63% for many decades

Multivitamins are recommended to address micronutrient insufficiencies as determined by individual deficiencies and suboptimal intake

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