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While healthy fat tissue contains beneficial immune cells, excess weight transforms it into an inflammatory factory, releasing pro-inflammatory mediators like TNF-, IL-6, and free fatty acids

The first step of glutathione synthesis involves the formation of glutamylcysteine from glutamate and cysteine in an ATP dependent reaction catalysed by glutamate-cysteine-ligase (GCL) which requires either Mg 2+ or Mn 2+ as a cofactor

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Contact your GP if fatigue is severe, significantly impairs daily functioning, persists despite self-management strategies, or is accompanied by signs of dehydration, hypoglycaemia, persistent vomiting, or symptoms suggesting nutritional deficiency such as pale skin or muscle weakness

[1] [2] Short-chain fatty acids (primarily acetic, propionic, and butyric acids), which microganisms form in the intestines, bind to the FFAR2 and FFAR3 receptors on K cells and L cells to stimulate their respective production and secretion of GIP [3] and GLP-1