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As a reference, recombinant IGF-1 injections have a half-life of under 6 hours when given subcutaneously as a treatment of growth failure and slower development of children due to poor IGF-1 levels

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The STEP 1 trial extension study, published in Diabetes, Obesity and Metabolism , found that participants who discontinued semaglutide after 68 weeks regained approximately two-thirds of their lost weight within one year of stopping treatment