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Investigators must ensure that all samples (subjects and controls) are collected and processed as uniformly as possible given that most platforms can quite easily reveal signs of improper handling (e.g., hemolysis, anticoagulation additives, improper solvent use, etc.), nutritional supplementation, environmental exposures, and fasting status

Autophagy 15(3):453465 Hubbard BP, Sinclair DA (2014) Small molecule SIRT1 activators for the treatment of aging and age-related diseases

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Unlike more severe TBIs, concussions often do not present visible physical trauma or external signs of injury with a delayed onset of symptoms that vary widely 9