paraxanthine catalase glutathione Paraxanthine, a caffeine metabolite, has

Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 66:10326

The genetic or pharmacological restoration of GPX4 suppresses neutrophil ferroptosis and abrogates downstream autoimmunity, underscoring GPX4 as a checkpoint that constrains iron-driven inflammation (206, 217)

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This aligns with Hubermans biohacking mindset of eliminating chronic cellular stress to optimize system-wide performance