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In 14 patients with coronary artery disease and good LV function, intravenous GLP-1 infusion improved global and regional wall LV function on dobutamine stress echocardiography compared with control [92]
For patients with active gout history or baseline hyperuricemia, tirzepatide may offer advantages because dual GIP/GLP-1 activation produces slightly less rapid weight mobilization than semaglutide alone, potentially reducing purine release
Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway
If no abnormalities are found, a repeat colonoscopy is generally recommended in 10 years for individuals at average risk
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