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doi: 10.1074/jbc.RA119.010949 42 SwaminathanS

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An LVEF of less than 40% is indicative of systolic heart failure (52)

Importantly, most GLP-1 receptor agonists carry a boxed warning about the risk of thyroid C-cell tumors and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)