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These plots serve as critical tools for assessing the predictive performance of the models by visualizing their ability to approximate the experimental solubility of rivaroxaban in mixed solvent systems

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The study included a 26-week treatment period including up to six weeks of dose escalation, followed by a 6-week post-treatment follow-up, extending to week 32

Commenters asserted that the proposals are not authorized by and conflict with CMS's statutory authority, are arbitrary and capricious, and require new unsupported expansive interpretations of the statute