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It can, however, be cleaved at the stalk to release the extracellular domain, which circulates in the plasma as soluble DPP-4 (aa 49-766), but is also present in other bodily fluids such as seminal fluid and cerebrospinal fluid

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The therapeutic approach for HCC remains focused on curative treatments for early stages (resection, ablation, transplantation) or palliative systemic therapies for advanced disease (tyrosine kinase inhibitors [TKIs] and VEGF inhibitors) and immunotherapies (i.e., programmed death 1 [PD-1]/programmed cell death-ligand 1 [PD-L1] inhibitors and anti-cytotoxic T-lymphocyte-associated protein 4 [CTLA-4] antibodies) (Sadagopan et al., 2024