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The GIP receptor activation complements these effects by further enhancing insulin secretion and may contribute to improved lipid metabolism

encoded by the PSENEN gene), high mobility group box 1 (encoded by the HMGB1 gene), and lysine demethylase 6A (encoded by the KDM6A gene)

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IDH1 mutations cause significant changes in enzymatic reactions, catalyzing the large-scale conversion of -ketoglutarate (2-KG) to 2-hydroxyglutarate (2-HG), and cause significant changes in the cells metabolic system

Accordingly, both APR and GCL in the primary metabolic pathway are activated upon oxidation whereas the activity of enzymes that are part of the secondary pathway, APK and SAL1, is attenuated