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Emergency medical attention is required if your blood pressure is very high (180/120 mmHg or higher) or if you have severe symptoms such as chest pain, severe headache with visual disturbance, difficulty breathing, or loss of consciousness

But there are a few things to be aware of: Scalp Irritation: If the concentration is too high, some people may have mild redness or itching

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Additionally, the tissue inhibitor of metalloproteinase 1 (TIMP1), which has been speculated to act as a protective agent for the basal membrane of Schwann cells, has been found upregulated in injured nerves (La Fleur et al., 1996)

But it is generally going to correlate