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It should be noted, however, that these observations were made using animal microsomes and thus their relevance to acetaminophen metabolism in humans still needs to be investigated
13: 110112 1985 Mass Spectrometry for ID and Quantification of Glucuronides Mass spec primarily provides M+H + , and loss of 176 (sugar) which can also occur via in source fragmentation. No information on the site of glucuronic acid attachment (if multiple plausible sites) or isomerization (acyl migration) is provided via MS. Site of attachment may be possible if other fragmentations of drug occur with retention of sugar
Basic Res Cardiol 116:32
[DOI] [PubMed] [Google Scholar] 62.Douton J.E., Augusto C., Stoltzfus B., Carkaci-Salli N., Vrana K.E., Grigson P.S
The trade-off is significant: 60-70% of the peptide is lost during nasal absorption, meaning you need 2-3 times the dose to achieve equivalent melanocortin receptor activation
