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2.4 Metabolic and mitochondrial dysfunction in diabetes An animal experiment using db/db mice, a model of type 2 diabetes, demonstrated that disturbances in circulatory metabolism and brain energy metabolism, particularly mitochondrial dysfunction, may contribute to cognitive impairment

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doi: 10.1016/j.autneu.2013.12.007 108

Answer: Reported tolerability of these peptides is generally favorable in the literature, but they are not FDA-approved drugs, long-term human safety data is limited, and use should always be medically supervised

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