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Three key findings emerged from this study: (1) PRMT1 upregulation in injured TECs drives UBE2m methylation at R169, (2) methylated UBE2m promotes NEDD4 neddylation and subsequent PPAR ubiquitination, and (3) this pathway is clinically relevant in stone patients, correlating with renal function decline

This matters because mainstream medicine overwhelmingly treats these conditions as separate problems requiring separate solutions

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10.1016/B978-0-7020-5307-8.00020-X Supplements to Clinical neurophysiology 111 ZhangH.ZhangL.ZhouD.HeX.WangD.PanH.et al (2017)

According to our researches, PQQ decreased MDA (Fig