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Most vaccines are well-tolerated and offer protection from serious, life-threatening diseases

No regulatory vetting for consumer use: There is no approved label, no established consumer dosing, and no post-marketing safety surveillance, because larazotide was never approved

Effective preventative measures for patients at risk for cholelithiasis include a slower rate of weight loss, increasing/including some dietary fat in the diet (assuming the patient has been on a very low-calorie diet containing little or no fat), or administration of ursodeoxycholic acid

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IGF-1 is a growth factor, and chronically elevated levels carry theoretical concerns about promoting the growth of pre-existing neoplasms