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The comparator groups differed among studies, with some employing placebo controls (e.g., PIONEER-6, Gerstein 2019), others using active comparators such as sitagliptin, glimepiride, DPP-4 inhibitors, or SGLT2 inhibitors, and some utilizing standard care or intensive lifestyle interventions as the control

A 24-year-old with chronic inflammatory problems since infancy, who had tried many treatments, found that within hours of taking .25mg, his hunger and blood pressure had normalized, and his fatigue, brain fog, and inflammatory issues were substantially reduced

Additionally, GLP-1 receptor agonists suppress glucagon secretion from pancreatic alpha cells, further helping to lower blood glucose levels

Safer DJ

On Thursday, Eli Lilly announced promising Phase 3 results for orforglipron, its once-daily oral GLP-1 pill