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At the same time, semaglutide reduces the release of another hormone called glucagon, which raises blood sugar

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Additionally, new or worsening constipation accompanied by unexplained weight loss (beyond expected therapeutic weight reduction), persistent changes in stool caliber, or alternating constipation and diarrhea warrants evaluation to exclude structural or neoplastic causes, particularly in patients age 45 or older or those with family history of colorectal cancer

Depression was the most commonly reported adverse event (n = 187