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E15, V19, I23, L26 as well as G2, a residue critical for receptor activation 19 , were mutated and variants tested for human GLP-1R potency and maximum activation compared to GLP-1-Fc(4) in the cAMP accumulation assay

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Insufficient levels of the thyroid hormones thyroxine (T4) and triiodothyronine (T3) can cause health problems such as fatigue, hair loss, weight gain, and sensitivity to cold