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Our study suggests that targeting GPR17 with antagonists or inverse agonists may lead to enhanced GLP-1 secretion and could be an additional approach for treatment of metabolic diseases such as type 2 diabetes and obesity

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Safety and efficacy of exenatide once weekly plus dapagliflozin once daily versus exenatide or dapagliflozin alone in patients with type 2 diabetes inadequately controlled with metformin monotherapy: 52-week results of the DURATION-8 randomized controlled trial

BPC-157s shorter half-life means it works in more concentrated bursts, providing high local activity before clearance