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Collagen peptides, having no significant side effects in people who arent allergic, are the closest to risk-free as you can get with a consumer health product.6 Tesamorelin, at least among our recommendations, is the next best thing: two studies describe it as generally well tolerated, and its most common side effects in indicated users injection site reactions, joint and muscle pain are mild compared to other therapeutic peptides.10 11 Mostly ditto for ipamorelin and TB4, except theyre often combined with peptides associated with more serious health concerns like CJC-1295 or BPC-157