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In leave-one-out analyses, the pooled estimate remained in the same direction when omitting each study in turn (SMD range 1.36 to 0.82

Patients with GATM deficiencies have milder clinical manifestations which are generally limited to moderate intellectual disability and language disorder

The drug part of a class of medicines known as JAK inhibitors is the first approved treatment in the United States for the condition, which affects more than 300,000 people in the country each year, according to the FDA

What matters most is consistent use, adequate protein intake, resistance exercise, and close medical monitoring

Maximum benefits usually emerge after several months on the maintenance dose