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NICE recommends Saxenda only for adults within specialist weight management services (Tier 3 or 4), with specific BMI thresholds and conditions

Michigan restricted Wegovy, Zepbound, and Saxenda to patients classified as morbidly obese who have exhausted other weight loss interventions and are using the drug to avoid bariatric surgery

doi: 10.1177/0310057X1604400410

GLP-1s have a host of knock-on effects

In addition to those taking the medications listed above, certain people should avoid berberine due to its risk for more serious health complications: Berberine is not safe to use during pregnancy or while breastfeeding