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To overexpress astrocytic MAOB in the IL cortex of MAOB KO mice, we bilaterally microinjected AAV-GFAP104-MAOB-2A-EGFP or AAV-GFAP104-GFAP in the IL, following the same procedures described above

The key takeaways about glutathione IV versus oral supplementation center on bioavailability, safety profile, cost, and regulatory status

Glutathione is a naturally occurring antioxidant produced in the liver that helps neutralise harmful free radicals and supports detoxification

However, it is present in cortical glial cells, where it may be upregulated in amyotrophic lateral sclerosis 48

El-Hattab, AW, Adesina, AM, Jones, J, Scaglia, F 2015, MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options, Molecular genetics and metabolism , vol