streptozotocin-induced T1DM) and T2DM (db/db mice, Zucker rats) ( Podocytes also present an insulin-dependent alternative pathway, the cyclic guanosine monophosphate(cGMP)-dependent protein kinase G (PKG), from which the PKG isoform I-alpha levels are increased in glomeruli of the hyperinsulinemic Zucker rats ( An important player in podocytes physiology is the protein nephrin, a podocyte-specific protein, which is responsible for the maintenance of the integrity of the filtration barrier
doi: 10.3389/fncel.2020.00204 Received 16 March 2020 Accepted 10 June 2020 Published 04 September 2020 Volume 14 - 2020 Edited by Mathieu Letellier, UMR5297 Institut Interdisciplinaire de Neurosciences (IINS), France Reviewed by Thomas Edward Chater, RIKEN Brain Science Institute (BSI), Japan
In vitro, Rg1 treatment (12.5 M) exerted a cardioprotective effect through regulating mitochondrial dynamics, and achieved by moderating glutamate dehydrogenase (GDH) and MFN2 dysregulation
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