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Some proponents argue that yerba mate's effect on insulin sensitivity or glucose handling could indirectly benefit the GLP-1 system, but this mechanism is speculative

Thus, adequate provision of dietary creatine may be necessary for maintaining homeostasis and optimal health in humans (Brosnan and Brosnan 2007), particularly for vegan athletes who generally have low intake of creatine and its precursors (arginine, methionine and glycine) (Rogerson 2017)

This further supports the superiority of GLP1/E vs

Found in nature and also obtainable from dietary sources such as red meat, fish, and dairy, L-carnitine is integrated through foods or widely available supplements, used for various purposes, including enhancing athletic performance, promoting weight loss, and supporting cognitive function

A 2017 report in The Lancet followed 1,505 people on liraglutide (Victoza, Saxenda) and 749 on a placebo