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307 Moreover, beyond the increased shear forces sensed by endothelial cells and HSCs to secrete more HGF after PHx, these extracellular stimuli can be sensed directly by hepatocytes and result in the activation or inactivation of YAP

Drug Test Anal 4, 876-81 (2012)

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Putting the trial numbers into perspective Historically, anti-obesity drugs produced average weight losses in the single digits (510%), and even the best options rarely approached double-digit percentages at the population level

Firstly, mTORC1/S6K1 activates transcription factor sterol-regulatory element binding proteins (SREBP), promoting fat synthesis