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Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium

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In addition, a study using LPS-exposed RAW264.7 macrophages and a DSS-triggered colitis murine model demonstrated that GLP-1 attenuates inflammatory responses by inhibiting the phosphorylation process of AKT/NF-B and MAPK signal-transducing molecules under in vitro and in vivo circumstances, respectively [219]