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The possibility that GSHee directly blunted the mechanisms by which fentanyl depressed breathing is supported by the evidence that GSHee did not affect baseline Vt values but markedly blunted the magnitude and duration of fentanyl-induced reduction fentanyl-induced reduction in Vt

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Important Note on the Evidence Base Important note on the evidence base: The Dihexa research literature is entirely preclinical rodent behavioral models, in vitro hippocampal neuron culture, and mechanistic work characterizing HGF/c-Met-dependent signaling