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The latter binds to RAGE, leading to an increase in NF-B-dependent pro-inflammatory gene expression, suggesting that CML-S100A8/S100A9 generated in inflammatory lesions can elicit a RAGE-dependent inflammatory response (129)

This means that they can pass a normal gene, carrier state or disease state to their children, depending on the genetics of their partner

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Because that is ultimately what every DoD evaluator is asking: does this solve a real operational problem, and can this team deliver