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50, 51, 52 It is also known that the adaptive response induced by 4-hydroxynonenal, one of the important determinants of oxidative stress, is positively mediated by gene expression of cyto-protective protein (Nrf2/Keap-1) pathway

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TMAVA, a metabolite of intestinal microbes, is increased in plasma from patients with liver steatosis, inhibits -Butyrobetaine hydroxylase, and exacerbates fatty liver in mice

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Crystal structure of the GLP-1 receptor bound to a peptide agonist