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Therefore, understanding what factors can negatively modulate tight junction permeability and how pharmacological approaches such as LA act to protect or restore the tight junction barrier before or after injury is critical for developing preventative or therapeutic approaches

Therapy with a GLP-1 RA or sodium-glucose cotransporter 2 inhibitor (SGLT2 inhibitor) that has proven CV benefit is recommended for initial therapy, with or without metformin based on glycemic needs, in patients with indicators of high-risk or established CV disease

Never stop or change blood pressure medications without medical advice

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GLP-1 receptors are not just found in the pancreas and gut