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GLP-1 receptor agonists promote myocardial glucose uptake and utilization, reduce oxidative stress, and inhibit cardiomyocyte apoptosis (52)

(2021) reported lower Clostridium group IV in PD as well as no strongly associated taxa with levodopa (L-DOPA) use, although preliminary data suggest Clostridium cluster IV may be linked to short-term motor-symptom response to L-DOPA, which deserves a thorough controlled validation

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TCAs (e.g., Amitriptyline, Imipramine) primarily inhibit 5-HT/NE reuptake, elevating synaptic neurotransmitter levels [130]