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The strengths of this study include multi-center design and homogenous (post-cardiovascular surgery) patient population

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TMAO reduces bile acid pools, inhibiting FXR activity, disrupting bile acid-FXR signaling, and upregulating pathways worsening hepatic steatosis, as confirmed in HFD-fed C57BL/6J mice and human samples (154)

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The combination of hyaluronic acid enhances moisture retention in skin and joints , biotin supports keratin production for healthy hair and nails , vitamin C acts as a cofactor for collagen synthesis , and probiotics promote gut health for improved nutrient absorption